Endocrine Abstracts

Papillary thyroid carcinoma (PTC) is a malignant tumour of follicular cell origin that is characterized by a broad diversity of histological variants. A genesis of multifocal PTC may be explained by both intrathyroid tumour dissemination and multiple focuses of tumour origination. A combination of two different focuses of PTC characterized by various molecular alterations of tumour cells in one thyroid could be rarely occurred. Follicular variant has similar clinical behaviour...

Female menopause is an inevitable condition caused by biological programmed primary ovarian failure and resulting in an abrupt deficiency in estrogens. Men may experience a gradual decline in androgen levels with increasing age but, in contrast to the phenomenon in women, it is questionable whether this is an inevitable biologically programmed event or whether it is related to other age- related changes or to long-term effects of lifestyle factors.Hormon...

Central hypogonadism (CH) is a syndrome that can be revealed in women with hypoestrogenic amenorrhea due to the lack of normal response of gonadotropins to the hypoestrogenemia. CH can be caused by organic lesion of the hypothalamo-pituitary region or has idiopathic character – without any structural background. This syndrome is often called ’hypogonadotropic hypogonadism’, but LH and FSH levels within ’normal’ laboratory range does not exclude CH beca...

IntroductionCoronavirus disease (COVID-19) caused by SARS-CoV-2 infection, resulted in serious respiratory and other systemic complications, has spread worldwide since December 2019. In patients with the infection, many organ systems can be involved with potentially fatal results due to robust and disorganized systematic immune activation.The state of the artSince the outbreak of the SARS-CoV-2 pandemic, many...

IntroductionThe novel COVID-19 has been rapidly expanding and causing many deaths all over the world, since December 2019. The health condition and the coexistence of other diseases may affect the severity of SARS-CoV-2 infection.The state of the artPCOS is a common endocrine and metabolic disorder, afflicting females of reproductive age, with an incidence up to 10%. It is a heterogeneous clinical syndrome, c...

Section 1: Case history: A 53 year old male of Chinese ethnicity presented to hospital with a fall and a long lie. He had a heavy meal for dinner, and he fell later in the evening after standing from the sofa. He lacked strength in his limbs and could not stand up again. He was on the floor for 7 hours before he could shuffle his way to the phone and call for help. On examination he had MRC grade. power in the proximal arms and MRC grade. hip. flexion. Sensation was normal. He...

Introduction: Prolonged use of Metformin is associated with the development of vitamin B12 deficiency. The aim of our study was to investigate the relationship of clinical manifestations similar to diabetic polyneuropathy with vitamin B12 levels in patients with type 2 diabetes mellitus.Materials and methods: We examined 35 patients with type 2 diabetes taking Metformin. Mean age 55.9±11.5 years, mean diabetes duration 9.2±7.7 years. All patients w...

Introduction: Pheochromocytomas (PCCs) or adrenal paragangliomas are neuroendocrine non-epithelial catecholamine-producing tumors with a wide range of cardiovascular, metabolic, neurological manifestations, which may complicate the early diagnosis of the disease in some cases. Materials and methods: We analyzed data from 89 patients (58 women, 31 men, median age 52 years) with histologically and immunohistochemically verified PCCs including 4 patients wi...

Introducton: Telemedicine consultations (TMC) are a useful tool for ensuring communication between medical specialists, especially in a large country and in the era of COVID-19. It is important to study the needs and possibilities of TMC for various diseases, in particular, for the pathology of the parathyroid glands.Materials and methods: TMC between regional health specialists and Endocrinology Research Centre (Moscow, Russian Federation) were conducte...

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT) and extremely rare endocrine malignancy during pregnancy. Different maternal and fetal/neonatal complications of PHPT occur in 67 and 80% of untreated cases respectively, probably more due to severe hypercalcemia.The diagnostic and therapeutic approaches are limited in pregnant women and require individual risk-benefit assessment.Aim: We present a case of PC mani...